a purple cap vial of Tirzepatide Mounjaro

Tirzepatide in Bangkok – Current Update | 2024/2025

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Tirzepatide, a novel dual GIP and GLP-1 receptor agonist, is gaining attention for its effectiveness in managing Type 2 diabetes and promoting significant weight loss. Branded as Mounjaro for diabetes treatment and Zepbound for weight loss, Tirzepatide is administered as a weekly injection, offering a promising option for those seeking effective solutions. At H.U.M. Clinic, a leading weight loss clinic in Bangkok, Thailand, we provide comprehensive care with these cutting-edge treatments.
As a weight loss injection, Tirzepatide has shown remarkable results, making it a preferred choice for patients aiming to manage their weight effectively. Whether you’re considering Tirzepatide for its dual benefits or exploring weight loss pens, H.U.M. Clinic in Bangkok offers expert guidance and personalized care to help you achieve your health goals.

What is Tirzepatide?

Tirzepatide is a groundbreaking medication designed as a dual GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) receptor agonist. Administered once weekly, this injectable drug offers a novel approach to managing Type 2 diabetes and aiding in significant weight loss. Its dual action targets both blood sugar regulation and appetite control, making it a versatile treatment option.

Tirzepatide (Mounjaro) Approved for Diabetes Type 2

Mounjaro (Tirzepatide) has been approved as the therapeutic use as an adjunct therapy to exercise and diet to improve glycemic control in Type 2 diabetes adults by US FDA since May 13, 2022. Mounjaro works by enhancing insulin secretion and lowering blood sugar levels. Its dual receptor action offers improved glycemic control compared to traditional therapies, providing patients with a more effective treatment option for diabetes management.

Tirzepatide (Zepbound) Approved for Weight Loss

Zepbound (Tirzepatide) has been approved as the new medication for Chronic Weight Management by US FDA since November 08, 2023. Unlike Mounjaro, which focuses on diabetes, Zepbound is specifically designed to aid in significant weight reduction. By reducing appetite and promoting a feeling of fullness, Zepbound helps individuals achieve substantial and sustained weight loss. The key difference between these two brands lies in their primary indication—Mounjaro for diabetes and Zepbound for weight loss.

What is New with Dual GIP & GLP1-RA?

Tirzepatide introduces a breakthrough in diabetes and weight management by harnessing the dual-action mechanism of GIP (Glucose-Dependent Insulinotropic Polypeptide) and GLP-1 (Glucagon-Like Peptide-1) receptor agonists. This innovative approach sets it apart from traditional single-receptor therapies, offering enhanced benefits in both glycemic control and weight loss.

Dual Receptor Agonism Explained

  • GIP and GLP-1 Mechanisms: Tirzepatide stimulates insulin secretion, reduces glucagon levels, and slows gastric emptying by activating both GIP and GLP-1 receptors. This combined effect optimizes blood sugar control and supports weight reduction more effectively than traditional GLP-1 therapies.

Benefits Over Single-Action Therapies

  • Enhanced Efficacy: The dual mechanism offers superior outcomes in lowering HbA1c levels and promoting significant weight loss. Patients may experience greater improvements in metabolic health, making Tirzepatide a powerful option for managing Type 2 diabetes and obesity.
doctor explaining about the research clinic trial of Tirzepatide Mounjaro

Tirzepatide (Mounjaro) for Diabetes Treatment

Tirzepatide (Mounjaro) has emerged as a highly effective treatment for Type 2 diabetes, offering significant improvements in glycemic control. The dual-action mechanism of GIP and GLP-1 receptors allows Mounjaro to optimize blood sugar levels, making it a promising option for patients struggling with traditional therapies. Five of the clinical trials are now complete with published full-text articles (SURPASS 1 to 5).1

Efficacy in Glycemic Control

  • SURPASS-1 Study: This clinical trial demonstrated that Tirzepatide significantly reduced HbA1c levels, with many patients achieving target glucose levels. The study confirmed its superiority over placebo and traditional GLP-1 therapies.
  • SURPASS-2 and SURPASS-3 Studies: Further studies highlighted the enhanced efficacy of Tirzepatide compared to other diabetes medications like semaglutide. Patients experienced not only better glucose management but also substantial weight loss, improving overall metabolic health.
  • SURPASS-4 and SURPASS-5 Studies: These trials confirmed the long-term benefits of Tirzepatide, showing sustained glycemic control and cardiovascular risk reduction, further establishing it as a top choice for managing Type 2 diabetes.

Dosing and Administration

  • Flexible Dosing: Mounjaro is administered once weekly, with doses adjusted based on patient response and tolerance. The simplicity of weekly injections enhances adherence, making it a convenient option for long-term diabetes management.

How Effective is Tirzepatide (Zepbound) for Weight Loss?

Tirzepatide has emerged as a highly effective weight loss treatment, particularly for patients struggling with obesity. This section highlights key findings from clinical trials and real-world data, showcasing its potential as a leading weight management therapy.

Clinical Trial Evidence

  • SURMOUNT-1 Study: Conducted on individuals with obesity or overweight with related comorbidities, this trial showed an average weight reduction of up to 21% over 72 weeks. The results highlighted Zepbound’s superiority in promoting significant and sustained weight loss.2
  • SURMOUNT-2 Study: Focused on individuals with Type 2 diabetes and obesity, this trial demonstrated a weight loss of up to 15.7% over the same period. The study confirmed that Zepbound effectively manages weight even in populations with additional metabolic challenges.3

Real-World Outcomes

  • Comparison with Other Treatments: Zepbound has shown greater efficacy compared to other weight loss medications, including GLP-1 analogs like semaglutide. Its dual-action mechanism provides a more comprehensive approach to weight management, leading to better outcomes in both clinical and real-world settings.

Potential Side Effects and Considerations of Tirzepatide

Tirzepatide, used in both Mounjaro and Zepbound, offers significant benefits but comes with potential side effects like other types of GLP-1 (glucagon-like peptide-1) receptor agonist . It’s crucial to be aware of these effects and consult with healthcare professionals regularly.

Common Side Effects

  • Gastrointestinal Issues: Nausea, vomiting, and diarrhea are common, especially at the start of treatment. These symptoms often subside as your body adapts.
  • Decreased Appetite: Beneficial for weight loss, but can sometimes lead to unintended nutritional deficiencies if not monitored properly.

Serious Risks to Consider

  • Pancreatitis Risk: Rare, but severe abdominal pain could indicate pancreatitis. Seek immediate medical attention if this occurs.
  • Thyroid Tumor Concerns: Animal studies suggest a potential risk of thyroid C-cell tumors, though this hasn’t been confirmed in humans. Regular monitoring is advised.
Bangkok as a destination to get Tirzepatide

Why Consider Tirzepatide for Weight Loss in Bangkok?

Tirzepatide, especially in its form as Zepbound, offers a powerful weight loss solution, making it a popular choice in Bangkok. With accessibility and expert care at local clinics, patients can confidently pursue their weight loss goals.

Accessibility and Expertise

  • Authentic Medication: In Thailand, medications like Tirzepatide are approved by the Thai FDA, ensuring that patients receive genuine and safe products when prescribed by licensed clinics.
  • Expert Care: Bangkok is home to highly qualified healthcare providers, offering expert guidance and personalized treatment plans for weight loss.

Advantages for Bangkok Patients

  • Localized Support: Clinics in Bangkok are equipped to provide ongoing monitoring and support, crucial for effective weight loss with Tirzepatide.
  • Comprehensive Care: Alongside weight loss, patients can benefit from comprehensive health assessments, addressing all aspects of their well-being.

Can I Get Tirzepatide (Mounjaro/ Zepbound) in Bangkok?

Tirzepatide, known under the brand names Mounjaro for diabetes and Zepbound for weight loss, is anticipated to become available in Bangkok around Q4 2024 or Q1 2025. This section provides details on how and where to obtain these medications in Bangkok, along with important legal and regulatory considerations.

Availability in Bangkok

  • Tirzepatide Release: Mounjaro is expected to be accessible in Bangkok by late 2024 or early 2025. For up-to-date information on availability, patients should contact H.U.M. Clinic, a leading weight loss clinic in Bangkok.

Prescription Process and Regulations

  • Legal Considerations: Both medications will be available only through prescription, following Thai FDA approval. It’s essential to consult with a certified healthcare provider in Bangkok to obtain these treatments legally and safely.
  • Where to Get It: H.U.M. Clinic, located in Bangkok, is preparing to offer these medications as part of their comprehensive weight loss and diabetes management programs. Contact us for details on how to begin treatment.
FAQ and more questions

FAQ About Tirzepatide

How long does it take to see results with Tirzepatide?

Patients typically start seeing improvements in blood sugar levels and weight loss within the first few weeks of starting Tirzepatide. However, the most significant results are usually observed after several months of consistent use, depending on the dosage and individual response.

What should I do if I miss a dose of Tirzepatide?

If you miss a dose of Tirzepatide, it is advised to take the missed dose as soon as you remember, provided it’s within a few days of the missed injection. If it’s close to your next scheduled dose, skip the missed one and continue with your regular schedule. Do not double up on doses.

Is Tirzepatide suitable for long-term use?

Tirzepatide has been shown to be effective and safe for long-term use in managing Type 2 diabetes and weight loss, as long as it is monitored by a healthcare provider. Regular follow-ups and assessments are essential to ensure ongoing safety and efficacy.

Can Tirzepatide be used alongside other weight loss medications?

Using Tirzepatide with other weight loss medications should only be done under the guidance of a healthcare provider. Combining medications can increase the risk of side effects or interactions, so it’s crucial to consult your doctor before adding any other treatments to your regimen.

What should I avoid while taking Tirzepatide?

While using Tirzepatide, avoid consuming alcohol in excess, as it may increase the risk of low blood sugar (hypoglycemia). Additionally, it’s important to follow a healthy diet and exercise plan as advised by your healthcare provider to maximize the medication’s benefits.

Reference

  1. Tirzepatide for Type 2 Diabetes Mellitus <https://www.ncbi.nlm.nih.gov/books/NBK598991/)> ↩︎
  2. Tirzepatide Once Weekly for the Treatment of Obesity <https://pubmed.ncbi.nlm.nih.gov/35658024/> ↩︎
  3. Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial <https://pubmed.ncbi.nlm.nih.gov/37385275/> ↩︎

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